Science and Humanities - Chemistry

Science and Humanities Chemistry

Overview

Chemistry department is as a role model in the department of science and humanities. The strength of our division has been and continues to be potential for excellence in research career. Our faculty members are well qualified and motivated with a strong commitment to teaching and research. The commitment leads to promote integrated and collaboration researchers by national laboratory, university, industry and international delegates and also leads to support many number of funded projects and seminar funds from various sources UGC, DRDO, DST, SERB, DBT etc.,

Our division is fully equipped with excellent lab facilities including research repository. Incessantly sincere research efforts of our division become remarkable growth in the crucial short period. This provides exhilarating experience of learning and discovering in the ever changing scene of engineering and science and also creates the notable landmark in the history of Mohamed Sathak Engineering College.

The division of chemistry has been striving to provide core central facilities with modern instruments required to pursue research in various field of chemistry and we are also curious to promote the research collaboration with other departments. Some of the major facilities are available in the described below.

Vision

Our vision is to create a vibrant learning environment founded on value based academic principles that foster collaboration, a culture of accomplishment and strong support of ethnic and intellectual diversity wherein all involved shall contribute effectively, efficiently and responsibly.

Mission

The mission of the Chemistry department is to provide an excellent academic education to qualified students of diverse backgrounds. This is to be accomplished within an atmosphere of academic and research integrity, which fosters the highest standards in professional ethics and competence.

Highlights

• Well qualified Faculty

• Innovative teaching learning process

• Well Equipped R & D Lab

• DST-SERB Funded Projects

• Research Collaboration

• Student Teacher Parent Association

• Vibrant department Associations

• Water Analysing Centre

Lab Facilities

01. UV-Visible Spectrophotometer

02. FTIR- Spectrophotometer.

03. UV- Trans Illuminator

04. Submarine Gel-Electrophoresis

05. Ultra sonic cleaner

06. UV-Chamber

07. Digital Chemical balance (0.1mg accuracy)

08. Connectivity meter 304 (systronics)

09. Digital pH meter (systronics)

10. Digital potentiometer 318 (systronics)

11. Flame photometer

12. Muffle furnace

13. Hot air oven

14. Melting point apparatus

15. Turbidity meter

Faculty

Name Qualification Area of Specialization Designation
MOHAMED GANI M
M.Phil Chemistry Associate Professor
SIVABALAN G
M.Phil Chemistry Assistant Professor
SAKTHI KUMAR K
M.Phil Chemistry Assistant Professor
MOHANASUNDRAM D
M.Phil Chemistry Assistant Professor
ADWIN JOSE P
M.Phil Chemistry Assistant Professor
Dr. VADIVEL M
M.Sc and Ph.D Chemistry Assistant Professor
Dr. RAJESH J
M.Sc and Ph.D Chemistry Associate Professor
Dr. DHAVEETHU RAJA J
M.Sc and Ph.D Chemistry Associate Professor
Dr. GIRIJA A
M.Sc and Ph.D Chemistry Associate Professor
ABDUL SARDHAR A
M.Phil Chemistry Assistant Professor

Infrastructure

Research Achievements

The major focus of our research group is to find ways to enhance the antitumor activity of pyrimidine derivative ligands and its Cu, Zn, Pt, and Au complexes without side effect.

We have developed the chemistry of 3d-metal complexes showing light-induced DNA cleavage activity. Metal complexes with their versatile structures, redox behavior and physicochemical properties are found to be useful as highly sensitive diagnostic agents as exemplified by the bleomycins or cis-platin in chemotherapeutic applications. Designing molecules that cleave DNA at ~700 nm is of great importance in photodynamic therapy (PDT) of cancer because of significant skin penetration of light in the near IR region. We have prepared a pyrimidine derivative ligands-Transition metal (II) complexes which shows metal-promoted efficient DNA cleavage activity. Dhaveethu raja et. al., is currently working in designing and synthesizing different types of coordination and organometallic complexes which is continue involving in the studies of DNA- interaction, Antioxidant and MMT Cytotoxicity Assay.

Palaniandavar, et. al., recently reported that mixed ligand copper(II) complexes of diimines, that bind and cleave DNA. It also exhibits anticancer activity which is more efficient than that of cisplatin.

DNA Binding – Electronic absorption study

Electronic absorption spectroscopy is one of the most common ways to investigate the binding mode of DNA with metal complexes. In general, most drugs have three distinct modes of non-covalent interaction with DNA, intercalative association in which a planar, aromatic moiety slides between the DNA base pairs, DNA groove binding through a combination of hydrophobic, electrostatic, and hydrogen binding interactions, and external binding by electrostatic attraction.

The interaction of transition metal complexes with DNA has long been a subject of intensive investigation with the perspective of development of newer materials for application in biotechnology and medicine. These investigations have resulted in the synthesis of many new metal complexes, which bind to DNA by non-covalent interactions such as electrostatic binding, groove binding and intercalative binding. Hence, the current growing interest in small molecules that are capable of binding and cleaving DNA is related to their utility in the design and development of synthetic restriction enzymes, new drugs, DNA foot-printing agents, etc., and also to their ability to probe the structure of DNA itself.

Copper complexes of 1,10-phenanthroline and its derivatives are of great interest since they exhibit numerous biological activities such as antitumour, antimycobacterial,antimicrobial, activities etc. Moreover, considerable attention has been focused on the use of phenanthroline complexes as intercalating agents of DNA and as artificial nucleases.Copper(II) is known to play a significant role in biological systems and also as a pharmacological agent. Synthetic copper(II) complexes have been reported to act as potential anticancer and cancer inhibiting agents and a number of copper complexes have been found to be active both in vitro and in vivo.

Dr. J. DHAVEETHU RAJA,

PRINCIPAL INVESTIGATOR,
DST- SERB PROJECT,
CHEMISTRY DIVISION,
DEPARTMENT OF DASH,
  • S.No. Title of the Project Funding Agency & Sanction Number Period Sanctioned amount in Rs.
    1. Synthesize of Antitumor active Pyrimidine Derivative Ligands and its Cu, Zn, Pt and Au Complexes SERB, DST & SERB/F/1707/2012-13 dated 22.06.2012 2012 - 2015 25,75,000/-